Antihistamine (non-sedating / second-generation H1 antagonist) Oral
Loratadine
Loratadine
CPG Reference
Authorised Medications — Loratadine (Lorastyne)
Indications
- ✓ Symptomatic urticaria (without evidence of anaphylaxis)
Contraindications
- ✕ Children < 30 kg
- ✕ Hypersensitivity to loratadine
Precautions
- ⚠ Severe hepatic impairment
- ⚠ Elderly: risk of sedation and anticholinergic effects increased
- ⚠ Not to be administered within 24 hours of previous antihistamine dose without ASMA approval
Dosing
Adult
Amount 10 mg tablet
Route Oral
Repeat Single dose only
Max dose 10 mg (single dose only)
Single dose only — do not repeat without ASMA approval
Paediatric (> 30 kg)
Amount 10 mg tablet
Route Oral
Repeat Single dose only
Max dose 10 mg (single dose only)
Contraindicated in children under 30 kg. Single dose only.
Side Effects & Notes
Side Effects
- • Sedation (risk increased in elderly)
Drug Interactions
- ⚠ Previous antihistamine dose within 24 hours — do not administer without ASMA approval
Clinical Notes
- → Antihistamines have NO role in the treatment or prevention of respiratory or cardiovascular symptoms in acute anaphylaxis
- → Loratadine is indicated ONLY for symptomatic urticaria WITHOUT evidence of anaphylaxis — if anaphylaxis is suspected, administer adrenaline, not loratadine
- → If patient has decreased alertness after receiving a non-drowsy antihistamine (such as loratadine) prior to EHS arrival, suspect anaphylaxis